Isabel Company-Ricart, Servicio de Cirugía General y del Aparato Digestivo, Hospital Universitario Dr. Peset, Valencia, España
Marta Córcoles-Córcoles, Servicio de Cirugía General y del Aparato Digestivo, Hospital Universitario de La Plana, Vila-real, Castellón, España
Juan C. Bernal-Sprekelsen, Servicio de Cirugía General y del Aparato Digestivo, Hospital Universitario Dr. Peset, Valencia, España
Segundo A. Gómez-Abril, Servicio de Cirugía General y del Aparato Digestivo, Hospital Universitario Dr. Peset, Valencia, España
Pararectal gastrointestinal stromal tumors (GIST) are rare neoplasms that supose a surgical challenge. We report a 64-year-old female with a 53 × 30 mm intersphincteric mass. GIST diagnosis was confirmed via biopsy and CD117 positivity. Following six months of neoadjuvant imatinib, significant tumor shrinkage allowed for surgical excision through a direct perineal approach, preserving the anal sphincter. At 38 months of follow-up, the patient remains disease-free with normal continence. The perineal approach, supported by effective neoadjuvant therapy, represents a safe and functional surgical option for complex pelvic tumors.
Keywords: Gastrointestinal stromal tumors. Pararectal space. Imatinib. Neoadjuvant therapy. Perineum.